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  • The U.S. Food and Drug Administration has approved Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) as treatment option for chronic weight-loss in addition to a reduced-calorie diet and exercising.

    Using two separate drugs to shed pounds can be very effective you'll find combinations as you're watching FDA now awaiting approval. When dealing with weight loss and the people that go through it one should err along the side of caution and allow FDA do its job and demand some study be done so that the public recognizes the side effects and dangers of the medications before we take them. Keep in mind that drug companies come in business to earn money and that they would say anything to keep people on his or her medications.

    Researchers found out that participants taking this drug for any year, lost excess weight within one month and have kept the weight off through the 56 weeks of the study. Contrave can be a combination of the drugs naltrexone and bupropion, which seems to reflect a brand new trend of weight-loss drugs which are made up of multiple active ingredient, which can make them more effective and safer.

    Combo-pilling may be the newest fad or even better the newest to come under scrutiny and therefore it is just more publicly known recently, comb-pilling to lose weight has been around since the eighties. The biggest reason that employing a combination of pills is now popular may be the fact that by right now there aren't any long term prescription weightloss pills that have been approved by the FDA besides orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications although some people might of the combinations happen to be rejected or have yet to be approved by the FDA.

    Seizures are a side effect with Contrave and must not be taken in people who have seizure disorders. The drug can also raise blood pressure level and heartrate, and really should not be used in people with a history of cardiac arrest or stroke in the last six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy using the drug.

    The FDA also warned that Contrave can raise blood pressure and heartbeat and must 't be used in patients with uncontrolled high hypertension, along with by you aren't heart-related and cerebrovascular (circulation system dysfunction impacting mental performance) disease. Patients using a history of cardiac arrest or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes which has a boxed warning to alert medical researchers and patients on the increased probability of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for stopping smoking.

    "There were no signs and symptoms of depression or suicidal thoughts in trial participants," said Fujioka.